Symptoms of Low Glutathione and How to Fix It Colair Beauty Glutathione have you heard of it? A little research & you will learn like I did. Symptoms if your glutathione may be low: Feeling run down or low energy Getting sick more Potentially dismantling all symptoms with this : r Hashimotos Glutathione deficiency can lead to a variety of signs and symptoms that affect your overall health. Here are some common signs to look out for: 1. **Increased Dark Spots** Glutathione Glutathione Deficiency: Are You At Risk?